Part I: Principles.- Section 1: Global Healthcare Challenge of the 21st Century and the Future of Chronic Disease.- The History and Evolution of Medicine.- Influences of the Nutrition Transition on chronic Disease.- Nutritional and Metabolic Wellness.- Nutritional Ecology and Human Health.- The Radial: Integrative and Functional MNT.- The Power of Listening and the Patient's Voice: "Please Hear Me". Section 2: Metabolic Characteristics and Mechanism of Chronic Disease.- Metabolic Correction Therapy: A Biochemical-Physiological Mechanisitc Explanation of Functional Medicine.- The Nutrition Assessment of Metabolic and Nutritional Balance.- IFMNT NIBLETS Nutrition Assessment Differential.- Nutritional Role of Fatty Acids.- Lipidomics: Clinical Application.- Structure: From Organelle and Cell Membrane to Tissue.- Protective Mechanisms and Susceptibility to Xenobiotic and Load.- Detoxification and Biotransformation.- Drug-Nutrient Interactions.- The Enterohepatic Circulation.- A NutritionalGenomics Approach to Epigenetic Influences on Chronic Disease.- Nutritional Influences on Methylation.- The Immune System: Our Body's Homeland Security Against Disease.- Allergy, Intolerance, and Sensitivity.- Infection: A Stealth Underlying Pathology of Chronic Disease.- Body Composition.- The Therapeutic Ketogenic Diet: Harnessing Glucose, Insulin, and Ketone Metabolism.- The GUT Immune System.- Centrality of the GI Tract to Overall Health and Functional Medicine Strategies for GERD, IBS, IBD.- The Microbiome and Brain Health.- The Role of Nutrition in Integrative Oncology.- The Microenvironment of Chronic Disease.- Chronic Pain.- Nutrition and Behavorial Health/Mental Health/Neurological Health.- Neurodevelopmental Disorders in Children.- Nutritional Influences on Hormonal Health.- Nutritional Influences on Reproduction: A Functional Approach.- Lifestyle Patterns of Chronic Disease.- Circadian Rhythm: Light-Dark Cycles.- Nutrition with Movement for Better Energy and Health. Mental,Emotional, and Spiritual Imbalances.- Part II: Practice.- The IFMNT Practitioner.- The Patient Story and Relationship-Centered Care.- The Nutrition-Focused Physical Exam.- Modifiable Lifestyle Factors: Exercise, Sleep, Stress, Relationships.- Developing Interventions to Address Priorities: Food, Dietary Supplements, Lifestyle, and Referrals.- Therapeutic Diets.- Dietary Supplements: Understanding the Complexity of Use and Applications to Health.- Clinical Approaches to Monitoring and Evaluations of the Chronic Disease Client.- Ayurvedic Approach in Chronic Disease Management.- Section 2: Cases & Grand Rounds.- Cardiometabolic Syndrome.- Revolutionary New Concepts in the Prevention and Treatment of Cardiovascular Disease.- Immune System Under Fire: The Rise of Food Immune Reaction and Autoimmunity.- Amyotrophic Lateral Sclerosis (ALS): The Application of Integrative & Functional Medical Nutrition Therapy (IFMNT).- Gastroenterology.- Respiratory.- The Skin, Selected Dermatologic Conditions and Medical Nutrition Therapy.- Movement Issues with Chronic Ill or Chronic Pain Patients.- Section 3: Practitioner Practice Resources.- Systems Biology Resources.- Initial Nutrition Assessment Checklist.- Nutritional Diagnosis Resources.- Specialized Diets.- Motivational Interviewing.- Authorization for the Release of Information.- Patient Handouts.