The authors are international authorities and leaders on the presented topics. All are fellows of the Institute of Mathematical Statistics and the American Statistical Association.

Jianqing Fan is Frederick L. Moore Professor, Princeton University. He is co-editing Journal of Business and Economics Statistics and was the co-editor of The Annals of Statistics, Probability Theory and Related Fields, and Journal of Econometrics and has been recognized by the 2000 COPSS Presidents' Award, AAAS Fellow, Guggenheim Fellow, Guy medal in silver, Noether Senior Scholar Award, and Academician of Academia Sinica.

Runze Li is Elberly family chair professor and AAAS fellow, Pennsylvania State University, and was co-editor of The Annals of Statistics.

Cun-Hui Zhang is distinguished professor, Rutgers University and was co-editor of Statistical Science.

Hui Zou is professor, University of Minnesota and was action editor of Journal of Machine Learning Research.

1. Introduction. 2. Multiple and Nonparametric Regression. 3. Introduction to Penalized Least-Squares. 4. Penalized Least Squares: Properties. 5. Generalized Linear Models and Penalized Likelihood. 6. Penalized M-estimators. 7. High Dimensional Inference 8. Feature Screening. 9. Covariance Regularization and Graphical Models. 10. Covariance Learning and Factor Models. 11. Applications of Factor Models and PCA. 12. Supervised Learning. 13. Unsupervised Learning. 14. An Introduction to Deep Learning.