EDITED BY

Professor Christopher E. M. Griffiths, OBE, MD, FMedSci, Foundation Professor of Dermatology, The Dermatology Centre, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester, UK.

Dr. Tanya O. Bleiker, FRCP, Consultant Dermatologist, Department of Dermatology, University Hospitals of Derby and Burton, Derby, UK.

Dr. Daniel Creamer, MD, FRCP, Consultant Dermatologist, Department of Dermatology, King's College Hospital, London, UK.

Dr. John R. Ingram, MA, MSc, DM(Oxon), FRCP(Derm), FAcadMEd, BJD Editor-in-Chief, Clinical Reader and Consultant Dermatologist, Division of Infection and Immunity, Cardiff University, Cardiff, UK.

Dr. Rosalind C. Simpson, PhD, MRCP(Derm), Associate Professor and Consultant Dermatologist, Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.

Acknowledgements ix

Preface xi

Glossary xiii

Abbreviations xiv

1 Introduction 1

2 Introduction to dermatological therapeutics 10

Part 1: Infections and Infestations 21

3 Viral infections 23

4 Bacterial infections and sexually transmitted bacterial diseases 45

5 Mycobacterial infections 86

6 HIV and the skin 98

7 Fungal infections 106

8 Parasitic diseases 124

9 Arthropods stings and bites 137

Part 2: Inflammatory Dermatoses 153

10 Psoriasis 155

11 Pityriasis rubra pilaris 175

12 Lichen planus and lichenoid disorders 180

13 Graft-versus-host disease 192

14 Eczematous disorders 199

15 Seborrhoeic dermatitis 222

16 Atopic eczema 226

17 Urticaria 236

18 Mastocytosis 250

19 Reactive inflammatory erythemas 254

20 Behcet disease 262

21 Neutrophilic dermatoses 267

22 Immunobullous diseases 276

23 Lupus erythematosus 300

24 Dermatomyositis 318

25 Sclerosis and morphoea 325

Part 3: Metabolic and Nutritional Disorders Affecting the Skin 343

26 Cutaneous amyloidoses 345

27 Cutaneous mucinoses 351

28 Porphyrias 355

29 Nutritional disorders affecting the skin 363

Part 4: Genetic Disorders Involving the Skin 373

30 Inherited disorders of epidermal keratinisation 375

31 Acquired and inherited hair disorders 388

32 Acquired and inherited disorders of pigmentation 411

33 Epidermolysis bullosa 427

34 Genetic disorders of collagen elastin and dermal matrix 436

35 Disorders affecting cutaneous vasculature 445

36 Congenital naevi 450

37 DNA repair disorders with cutaneous features 459

38 Hamartoneoplastic syndromes 464

39 Inherited metabolic disorders 470

Part 5: Psychological and Neurological Disorders and the Skin 475

40 Pruritus and prurigo 477

41 Mucocutaneous pain syndromes 482

42 Psychodermatology 486

Part 6: Skin Disorders Associated with Specific Cutaneous Structure 493

43 Acquired disorders of epidermal keratinisation 495

44 Acne 503

45 Rosacea flushing and blushing 522

46 Hidradenitis suppurativa 536

47 Disorders of the sweat glands 540

48 Acquired and inherited nail disorders 545

49 Acquired disorders of dermal connective tissue 562

50 Sarcoidosis and granulomatous skin disorders 576

51 Panniculitis 584

52 Lipodystrophies and other acquired disorders of subcutaneous fat 596

Part 7: Vascular Disorders Involving the Skin 605

53 Purpura 607

54 Vasculitis 613

55 Dermatoses resulting from disorders of the arteries and veins 627

56 Ulceration resulting from disorders of the veins and arteries 637

57 Disorders of the lymphatic vessels 642

Part 8: Skin Disorders Associated with Specific Sites Sex and Age 657

58 Dermatoses of the external ear 659

59 Disorders of the lips and mouth 662

60 Dermatoses of the eye and eyelids 684

61 Dermatoses of anogenital skin 693

62 Dermatoses occurring in pregnancy 714

63 Dermatoses of neonates 719

64 Dermatoses of infants 729

65 Infantile and congenital haemangiomas 743

Part 9: Skin Disorders Caused by External Agents 749

66 Cutaneous adverse reactions to drugs and radiotherapy 751

67 Dermatoses caused by cold and heat 769

68 Photodermatoses 775

69 Contact dermatitis 784

Part 10 Neoplastic Proliferative and Infiltrative Disorders Affecting the Skin 795

70 Benign melanocytic proliferations and melanocytic naevi 797

71 Benign keratinocytic acanthomas and proliferations 821

72 Cutaneous cysts 826

73 Lymphocytic infiltrates 829

74 Cutaneous histiocytoses 835

75 Soft¿tissue tumours and tumour¿like conditions 844

76 Tumours of skin appendages 857

77 Kaposi sarcoma 869

78 Cutaneous lymphomas 872

79 Basal cell carcinoma 890

80 Squamous cell carcinoma its precursors and skin cancer in the immunocompromised patient 901

81 Melanoma 917

82 Dermoscopy of melanoma and naevi 930

83 Merkel cell carcinoma 941

84 Cutaneous markers of internal malignancy 944

Part 11: Systemic Disease and the Skin 955

85 The skin and systemic diseases 957

86 Acute dermatoses 975

87 Differential diagnosis 981

88 Drugs in dermatology 990

Index 1006