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state of the art technologies and future developments in the field of
preclinical pharmaceutical research. A balanced mix of experts from academia
and industry give insight in selected new developments in the drug discovery
pathway. The topics cover the different parts of the drug discovery process,
starting with new developments in the target identification and validation
area. The lead generation part as a next step focuses on the requirements and
technologies to identify new small molecules as lead compounds for further
optimization; in a second section the technologies to identify biologics as
leads are addressed. The final part focuses on the pharmacological models and
technologies to characterize new compounds and the impact of biomarkers to facilitate
the transfer of drug candidates into the development phase.
state of the art technologies and future developments in the field of
preclinical pharmaceutical research. A balanced mix of experts from academia
and industry give insight in selected new developments in the drug discovery
pathway. The topics cover the different parts of the drug discovery process,
starting with new developments in the target identification and validation
area. The lead generation part as a next step focuses on the requirements and
technologies to identify new small molecules as lead compounds for further
optimization; in a second section the technologies to identify biologics as
leads are addressed. The final part focuses on the pharmacological models and
technologies to characterize new compounds and the impact of biomarkers to facilitate
the transfer of drug candidates into the development phase.
In depth insights into drug discovery and early drug development
Latest technologies of target discovery and lead generation
New approaches to transfer drug candidates to clinical development
Preface.-
Part 1. Historical View.- Drug discovery in the past and [...] 2. Target Discovery.- Emerging target families:
intractable targets. In vivo target validation especially for biological
targets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.- Sources for leads: natural products,
libraries. Screening: assays, readout, technology. Impact of structural
biology, fragment based screening/Virtual screening. Predictive in silico tools
of compound properties. High throughput synthesis. New compound classes:
Protein-Protein Interaction. Sources for biological leads/Screening of
biologicals.- Part 4. Test systems for
Efficacy and Safety.- In vitro
/ Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact
of biomarkers/personalized medicine. Simulating in vivo drug effects.
| Erscheinungsjahr: | 2016 |
|---|---|
| Fachbereich: | Chemische Technik |
| Genre: | Mathematik, Medizin, Naturwissenschaften, Technik |
| Rubrik: | Naturwissenschaften & Technik |
| Medium: | Buch |
| Reihe: | Handbook of Experimental Pharmacology |
| Inhalt: |
viii
341 S. 37 s/w Illustr. 63 farbige Illustr. 341 p. 100 illus. 63 illus. in color. |
| ISBN-13: | 9783319289120 |
| ISBN-10: | 3319289128 |
| Sprache: | Englisch |
| Herstellernummer: | 978-3-319-28912-0 |
| Ausstattung / Beilage: | HC runder Rücken kaschiert |
| Einband: | Gebunden |
| Redaktion: |
Nielsch, Ulrich
Jaroch, Stefan Fuhrmann, Ulrike |
| Herausgeber: | Ulrich Nielsch/Ulrike Fuhrmann/Stefan Jaroch |
| Auflage: | 1st ed. 2016 |
| Hersteller: |
Springer International Publishing
Springer International Publishing AG Handbook of Experimental Pharmacology |
| Verantwortliche Person für die EU: | Books on Demand GmbH, In de Tarpen 42, D-22848 Norderstedt, info@bod.de |
| Maße: | 241 x 160 x 24 mm |
| Von/Mit: | Ulrich Nielsch (u. a.) |
| Erscheinungsdatum: | 08.04.2016 |
| Gewicht: | 0,757 kg |
In depth insights into drug discovery and early drug development
Latest technologies of target discovery and lead generation
New approaches to transfer drug candidates to clinical development
Preface.-
Part 1. Historical View.- Drug discovery in the past and [...] 2. Target Discovery.- Emerging target families:
intractable targets. In vivo target validation especially for biological
targets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.- Sources for leads: natural products,
libraries. Screening: assays, readout, technology. Impact of structural
biology, fragment based screening/Virtual screening. Predictive in silico tools
of compound properties. High throughput synthesis. New compound classes:
Protein-Protein Interaction. Sources for biological leads/Screening of
biologicals.- Part 4. Test systems for
Efficacy and Safety.- In vitro
/ Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact
of biomarkers/personalized medicine. Simulating in vivo drug effects.
| Erscheinungsjahr: | 2016 |
|---|---|
| Fachbereich: | Chemische Technik |
| Genre: | Mathematik, Medizin, Naturwissenschaften, Technik |
| Rubrik: | Naturwissenschaften & Technik |
| Medium: | Buch |
| Reihe: | Handbook of Experimental Pharmacology |
| Inhalt: |
viii
341 S. 37 s/w Illustr. 63 farbige Illustr. 341 p. 100 illus. 63 illus. in color. |
| ISBN-13: | 9783319289120 |
| ISBN-10: | 3319289128 |
| Sprache: | Englisch |
| Herstellernummer: | 978-3-319-28912-0 |
| Ausstattung / Beilage: | HC runder Rücken kaschiert |
| Einband: | Gebunden |
| Redaktion: |
Nielsch, Ulrich
Jaroch, Stefan Fuhrmann, Ulrike |
| Herausgeber: | Ulrich Nielsch/Ulrike Fuhrmann/Stefan Jaroch |
| Auflage: | 1st ed. 2016 |
| Hersteller: |
Springer International Publishing
Springer International Publishing AG Handbook of Experimental Pharmacology |
| Verantwortliche Person für die EU: | Books on Demand GmbH, In de Tarpen 42, D-22848 Norderstedt, info@bod.de |
| Maße: | 241 x 160 x 24 mm |
| Von/Mit: | Ulrich Nielsch (u. a.) |
| Erscheinungsdatum: | 08.04.2016 |
| Gewicht: | 0,757 kg |
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