PART ONE: Central Concepts of Pathophysiology: Cells and Tissues

UNIT I: The Cell

1 Cellular Biology

2 Altered Cellular and Tissue Biology: Environmental Agents

3 The Cellular Environment: Fluids and Electrolytes, Acids and Bases

UNIT II Genes, Gene-Environment Interaction, and Epigenetics

4 Genes and Genetic Diseases

5 Genes, Environment-Lifestyle, and Common Diseases

6 Epigenetics and Disease

UNIT III Mechanisms of Self-Defense

7 Innate Immunity: Inflammation and Wound Healing

8 Adaptive Immunity

9 Alterations in Immunity

10 Infection

11 Stress and Disease

UNIT IV Cellular Proliferation: Cancer

12 Cancer Biology

13 Cancer Epidemiology

14 Cancer in Children and Adolescents

PART TWO: Pathophysiologic Alterations: Organs and Systems

UNIT V The Neurologic System

15 Structure and Function of the Neurologic System

16 Pain, Temperature Regulation, Sleep, and Sensory Function

17 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function

18 Alterations of the Brain, Spinal Cord, and Peripheral Nerves

19 Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder

20 Alterations of Neurologic Function in Children

UNIT VI The Endocrine System

21 Mechanisms of Hormonal Regulation

22 Alterations of Hormonal Regulation

23 Obesity, Starvation, and Anorexia of Aging

UNIT VII The Reproductive Systems

24 Structure and Function of the Reproductive Systems

25 Alterations of the Female Reproductive System

26 Alterations of the Male Reproductive System

27 Sexually Transmitted Infections

UNIT VIII The Hematologic System

28 Structure and Function of the Hematologic System

29 Alterations of Hematologic Function

30 Alterations of Hematologic Function in Children

UNIT IX The Cardiovascular and Lymphatic Systems

31 Structure and Function of the Cardiovascular and Lymphatic Systems

32 Alterations of Cardiovascular Function

33 Alterations of Cardiovascular Function in Children

UNIT X The Pulmonary System

34 Structure and Function of the Pulmonary System

35 Alterations of Pulmonary Function

36 Alterations of Pulmonary Function in Children

UNIT XI The Renal and Urologic Systems

37 Structure and Function of the Renal and Urologic Systems

38 Alterations of Renal and Urinary Tract Function

39 Alterations of Renal and Urinary Tract Function in Children

UNIT XII The Digestive System

40 Structure and Function of the Digestive System

41 Alterations of Digestive Function

42 Alterations of Digestive Function in Children

UNIT XIII The Musculoskeletal System

43 Structure and Function of the Musculoskeletal System

44 Alterations of Musculoskeletal Function

45 Alterations of Musculoskeletal Function in Children

UNIT XIV The Integumentary System

46 Structure, Function, and Disorders of the Integument

47 Alterations of the Integument in Children

UNIT XV Multiple Interacting Systems

48 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults

49 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

Glossary