Part I. Pharmacology of Cannabis and the Endocannabinoid System: 1. How cannabis works in the brain Ken Mackie; 2. The function of the endocannabinoid system Nathan D. Winters and Sachin Patel; 3. Synthetic cannabinoids Liana Fattore and Matteo Marti; Part II. The Changing Face of Cannabis: 4. The epidemiology of cannabis use and cannabis use disorder Deborah Hasin; 5. Is cannabis becoming more potent? Tom P. Freeman and Sam Craft; 6. Policy implications of the evidence on cannabis use and psychosis Wayne Hall and Louisa Degenhardt; Part III. Cannabis and the Brain: 7. The impact of pubertal exposure to cannabis on the brain: a focus on animal studies Erica Zemberletti and Tiziana Rubino; 8. The impact of cannabis exposure on the adolescent brain: humans studies and translational insights Jacqueline-Marie Ferland, Alexandra Chisholm and Yasmin L. Hurd; 9. Cannabis and cognition: an update on short- and long-term effects Lisa-Marie Greenwood, Valentina Lorenzetti and Nadia Solowij; 10. Is there a cannabis-associated psychosis subtype? Lessons from biological typing in the b-snip project, and implications for treatment Godfrey Pearlson and Matcheri S. Keshavan; Part IV. Cannabis, Anxiety and Mood: 11. Cannabis and anxiety Grace Lethbridge, Beth Patterson and Michael Van Ameringen; 12. Cannabis consumption and risk of depression and suicidal behaviour Gabriella Gobbi; 13. Cannabis and bipolar disorder Jairo Pinto and Mauren Leticia Ziak; Part V. Cannabis and Psychosis: 14. Cannabis and psychosis proneness Rajiv Radhakrishnan, Shubham Kamal, Sinan Guloksuz and Jim van Os; 15. Which cannabis users develop psychosis? Edoardo Spinazzola, Marta Di Forti and Robin M. Murray; 16. Cannabis causes positive, negative, cognitive symptoms and produces impairments in electrophysiological indices of information processing Ashley Martin-Schnakenberg, Mohini Ranganathan and D. Cyril D'Souza; Part VI. Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications: 17. Does cannabis cause schizophrenia? Emmet Power, Colm Healy, Robin M. Murray and Mary Cannon; 18. Postmortem studies of the brain cannabinoid system in schizophrenia Suresh Sundram, Brian Dean and David Copolov; 19. The endocannabinoid system in schizophrenia Paul Morrison; 20. Cannabidiol as a potential antipsychotic F. Markus Leweke and Cathrin Rohleder; 21. Genetic explanations for the association between cannabis and schizophrenia Sarah M. Colbert and Emma Johnson; Part VII. Cannabis and its Impact on Schizophrenia: 22. Acute effects of cannabinoids in people with a psychotic illness Suhas Ganesh, Cécile Henquet, R. Andrew Sewell, Rebecca Kuepper, Mohini Ranganathan and Deepak Cyril D'Souza; 23. Cannabis and the long-term course of schizophrenia Tabea SchoeleR; 24. Treating cannabis use in schizophrenia and other psychotic disorders Alexandria S. Coles, Ashley E Kivlichian, David J. Castle and Tony P. George; Part VIII. Special Topics: 25. Prenatal cannabis exposure: associations with development and behavior Sarah E. Paul, Cynthia E. Rogers and Ryan Bogdan; 26. Cannabis use and violence Giulia Trotta, Paolo Marino, Victoria Rodriguez, Robin M. Murray and Evangelos Vassos; 27. Cannabis withdrawal Jane Metrik and Kayleigh McCarty; 28. Cannabis and addiction Valerie Curran, Will Lawn and Tom P. Freeman; 29. Tobacco use among cannabis users: insights into co-use and why it matters for people with psychosis Rachel A. Rabin, Erin A. McClure and Tony P. George; 30. Cannabis addiction genetics Suhas Ganesh and Arpana Agrawal; 31. Snoozing on pot: cannabis and sleep Patrick D. Skosnik and Toral S. Surti; 32. Cannabinoids as medicines: what the evidence says and what it does not say Marco De Toffol, Elena Dragioti, Andre Ferrer Carvalho, and Marco Solmi.