Rohit Aggarwal, MD, MS

Associate Professor of Medicine

University of Pittsburgh

School of Medicine

Medical Director, Arthritis and Autoimmunity Center

Co-Director of the UPMC Myositis Center

Pittsburgh, PA 15260

USA

Chester V. Oddis, MD

Professor of Medicine

University of Pittsburgh

School Of Medicine

Director of the Myositis Center

Pittsburgh, PA 15260

USA

Foreword.- 1 Introduction to Myositis.- 2 Myositis Basics/Who Gets Myositis.- 3 Evaluating the patient with suspected myositis.- 4 Asymptomatic HyperCKemia.- 5 Clinical Features of Myositis Patients: Muscular Manifestations.- 6 Clinical Features of Myositis Patients: Skin Manifestations.- 7 Clinical Features of Myositis Patients: Lung Manifestations.- 8 Clinical Features of Myositis Patients: Cardiac Manifestations.- 9 Clinical Features of Myositis Patients: Juvenile Dermatomyositis clinical features.- 10 Clinical Features of Myositis Patients: Other manifestations: arthritis, Raynaud phenomenon, constitutional.- 11 Making the Diagnosis of Myositis: Beyond the History and Physical Examination: Definition and classification of Myositis.- 12 Making the Diagnosis of Myositis: Beyond the History and Physical Examination: Electrodiagnostic Testing.- 13 Making the Diagnosis of Myositis: Beyond the History and Physical Examination: Muscle biopsy and interpretation.- 14 Making the Diagnosisof Myositis: Beyond the History and Physical Examination: Skin biopsy and interpretation.- 15 Making the Diagnosis of Myositis: Beyond the History and Physical Examination: Lung biopsy and interpretation.- 16 Making the Diagnosis of Myositis: Beyond the History and Physical Examination: Muscle MRI.- 17 Making the Diagnosis of Myositis: Beyond the History and Physical Examination: Laboratory testing in myositis.- 18 Role of ANA and Myositis Autoantibodies in Diagnosis.- 19 Role of Myositis Autoantibodies in Management and Prognosis.- 20 Traditional Myositis Autoantibodies: Synthetase, Mi-2, SRP, Ku, PM-Scl, Ro, U1RNP.- 21 Dermatomyositis-associated Autoantibodies: TIF1-¿, NXP2, and MDA5.- 22 Newly described Myositis Autoantibodies: HMGCR, NT5C1A, SAE, PUF60.- 23 Myositis Mimics: The Differential Diagnosis of Myositis.- 24 Immune Mediated Necrotizing Myopathy (IMNM).- 25 Cancer Associated Myositis.- 26 Myositis Associated Interstitial Lung Disease.- 27 Pregnancy in Myositis.- 28 Pathogenesis of Myositis.- 29 Management Considerations: Pharmacologic intervention.- 30 Management Considerations:Special treatment considerations - JDM.- 31 Management Considerations: Special treatment considerations - Refractory skin rash and calcinosis.- 32 Management Considerations: Special treatment considerations - ILD.- 33 Role of Exercise in the Management of Myositis.- 34 Dietary Considerations in Myositis.- 35 Distinguishing Disease Activity and Damage in Myositis.