Chapter 1. NeurologicHistory & Examination

Neurologic examination ofsphincter function

Chapter 2. InvestigativeStudies

Neuromuscular imaging studies

Update on ultrasonography forneuromuscular diagnosis

Chapter 3. Coma

Introduction

Role of prefrontal cortex in consciousness

Causes of coma

Spontaneous intracranialhypotension as a cause of coma

Persistent vegetative state

New imaging insights intopersistent vegetative & minimally conscious states

Treatment of traumatic vegetative &minimally conscious states with amantadine

Chapter 4. ConfusionalStates

Drugs

Serotonin syndrome

Electrolyte disorders

Antidepressant-inducedhyponatremia

Endocrine & metabolic disorders

Mechanisms of impairedhypoglycemia sensing in treated diabetes

Nutritional disorders

Furosemide-induced thiaminedeficiency

Organ system failure

ICU delirium

Postoperative cognitivedysfunction

Meningitis, encephalitis & sepsis

Mechanism of N. meningitidis vascular spread

Dysregulated host inflammatoryresponse in tuberculous meningitis

CSF findings in HIV-infectedpatients with tuberculous meningitis

Tick-borne encephalitis & (re-emergent)yellow fever

Nipah virus encephalitis

Updated diagnostic testing forviral encephalitis

New recommendation on empiricaltreatment of toxoplasmosis in AIDS

Fexinidazole for treatment of Africantrypanosomiasis

Mechanism of meningeal invasion inleukemia

Chapter 5. Dementia& Amnestic Disorders

Introduction

Somatic neuronal mutations in aging and neurodegeneration

Differential diagnosis

Biomarker-based diagnostic algorithms for dementia syndromes

Neurodegenerativeproteinopathies

Tau folding in Alzheimer vs. Pickdisease

Tau-disrupted nucleocytoplasmictransport in Alzheimer disease pathogenesis

Contrasting mechanisms ofaggregate toxicity in neurodegeneration

Herpes simplex virus infection andAlzheimer disease

Inflammation in Alzheimer diseasepathogenesis

Meningeal lymphatics (glymphatics)in Alzheimer disease pathogenesis

Blood pressure and risk of Alzheimerdisease

Relation between epilepsy anddementia

Exercise training in dementia

Sex differences in Alzheimerdisease

Spatial navigation deficits asearly signs of Alzheimer disease

Subjective cognitive decline in relationto Alzheimer disease

Update on biomarkers for Alzheimerdisease

Concomitant neurodegenerativeproteinopathies

Update on clinical trials oftreatments for Alzheimer disease (eg, solanezumab, verubecestat)

Clinical and pathologicalcorrelates of primary progressive aphasia variants

New consensus guidelines fordiagnosis & treatment of dementia with Lewy bodies

Skin prions in Creutzfeldt-Jakobdisease infectivity and diagnosis

Other cerebral disorders

Shunting response to gait vs. dementia in normal pressurehydrocephalus

Normal pressure hydrocephalus vs.neurodegenerative ventriculomegaly

Mild traumatic brain injury & dementia

Systemic disorders

Subclinical hyperthyroidism &dementia

Pseudodementia

Features of memory impairment in depression

Amnestic syndromes

Update on antibody-mediatedencephalitis antigens & treatment

Chapter 6. Headache& Facial Pain

Migraine

Triptans, SSRIs & serotoninsyndrome

CGRP receptor-blocking monoclonalantibodies (eg, erenumab, fremanezumab)

Prochlorperazine plusdiphenhydramine vs. hydromorphone for IV migraine therapy

Vagus nerve