José Zubizarreta, PhD, is an associate professor in the Department of Health Care Policy at Harvard Medical School and in the Department Biostatistics at Harvard University. He is a Fellow of the American Statistical Association, and is a recipient of the Kenneth Rothman Award, the William Cochran Award, and the Tom Ten Have Memorial Award.

Elizabeth A. Stuart, Ph.D. is Bloomberg Professor of American Health in the Department of Mental Health, the Department of Biostatistics and the Department of Health Policy and Management at Johns Hopkins Bloomberg School of Public Health. She is a Fellow of the American Statistical Association, and she received the mid-career award from the Health Policy Statistics Section of the ASA, the Gertrude Cox Award for applied statistics, Harvard University's Myrto Lefkopoulou Award for excellence in Biostatistics, and the Society for Epidemiologic Research Marshall Joffe Epidemiologic Methods award.

Dylan Small, PhD is the Universal Furniture Professor in the Department of Statistics and Data Science of the Wharton School of the University of Pennsylvania. He is a Fellow of the American Statistical Association and an Institute of Mathematical Statistics Medallion Lecturer.

Paul R. Rosenbaum is emeritus professor of Statistics and Data Science at the Wharton School of the University of Pennsylvania. From the Committee of Presidents of Statistical Societies, he received the R. A. Fisher Award and the George W. Snedecor Award. He is the author of several books, including Design of Observational Studies and Replication and Evidence Factors in Observational Studies.

Part 1: Conceptual issues 1. Overview of methods for adjustment and applications in the social and behavioral sciences: The role of study design 2. Propensity score 3. Generalization and Transportability Part 2: Matching 4. Optimization techniques in multivariate matching 5. Optimal Full matching 6. Fine balance and its variations in modern optimal matching 7. Matching with instrumental variables 8. Covariate Adjustment in Regression Discontinuity Designs 9. Risk Set Matching 10. Matching with Multilevel Data 11. Effect Modification in Observational Studies 12. Optimal Nonbipartite Matching 13. Matching Methods for Large Observational Studies Part 3: Weighting 14.Overlap Weighting 15. Covariate Balancing Propensity Score 16. Balancing Weights for Causal Inference 17. Assessing Principal Causal Effects Using Principal Score Methods 18. Incremental Causal Effects: An Introduction and Review 19. Weighting Estimators for Causal Mediation Part 4: Machine Learning Adjustments 20. Machine Learning for Causal Inference 21. Treatment Heterogeneity with Survival Outcomes 22. Why Machine Learning Cannot Ignore Maximum Likelihood Estimation 23. Bayesian Propensity Score methods and Related Approaches for Confounding Adjustment Part 5: Beyond Adjustments 24. How to Be a Good Critic of an Observational Study 25. Sensitivity Analysis 26. Evidence Factors