VOLUME I

Part 1: Structure and Function of Bone, Joints, and Connective Tissue

1. Biology of the Normal Joint, 1 Carla R. Scanzello and Steven R. Goldring

2. Synovium, 20 Douglas J. Veale and Gary S. Firestein

3. Cartilage and Chondrocytes, 34 Ali Mobasheri, Mary B. Goldring, and Richard F. Loeser

4. Biology, Physiology, and Morphology of Bone, 60 Aline Bozec, Anika Grüneboom, and Georg Schett

5. Muscle: Anatomy, Physiology, and Biochemistry, 67 Mark S. Miller, Edward P. Debold, and Michael J. Toth

6. Biomechanics, 80 Kenton R. Kaufman and KaiNan An

7. Regenerative Medicine and Tissue Engineering, 92 Frank P. Luyten, Cosimo De Bari, and Francesco Dell'Accio

8. Proteinases and Matrix Degradation, 109 Yoshifumi Itoh

Part 2: Cells Involved in Autoimmune Diseases and Inflammation

9. Dendritic Cells, 132 Mansi Saxena, Nicolas Vabret, Luciana Ribeiro Muniz, and Nina Bhardwaj

10. Mononuclear Phagocytes, 149 Deborah R. Winter, Anna Montgomery, and Harris Perlman

11. Neutrophils, 161 Binita Shah, Nathalie Burg, and Michael H. Pillinger

12. T Lymphocytes, 182 Ralph C. Budd

13. B Cells, 199 Yong-Rui Zou, Christine Grimaldi, and Betty Diamond

14. Fibroblasts and Fibroblast-like Synoviocytes, 222 Christopher D. Buckley and Andrew Filer

15. Mast Cells, 241 Peter A. Nigrovic

16. Innate Lymphoid Cells and Natural Killer Cells, 254 Michael A. Paley and Wayne M. Yokoyama

17. Platelets and Megakaryocytes, 262 Eric Boilard and Peter A. Nigrovic

Part 3: Effector Mechanisms in Autoimmunity and Inflammation

18. Principles of Signaling, 273 Abel Suarez-Fueyo, Vaishali R. Moulton, and George C. Tsokos

19. The Immunologic Repercussions of Cell Death, 286 Helen M. Beere and Douglas R. Green

20. Innate Immunity, 306 Gregoire Lauvau and Steven A. Porcelli

21. Adaptive Immunity, 320 Martha S. Jordan and Gary A. Koretzky

22. Autoimmunity and Tolerance, 337 Dwight H. Kono and Argyrios N. Theofilopoulos

23. The Microbiome in Health and Disease, 355 Rob Knight

24. Metabolic Regulation of Immunity, 368 Ruoning Wang, Tingting Wang, and Stephen Tait

25. Genetics of Rheumatic Diseases, 378 Stephen Eyre and Anne Barton

26. Epigenetics of Rheumatic Diseases, 393 Amr H. Sawalha and Matlock A. Jeffries

27. Complement System, 409 V. Michael Holers and Leendert A. Trouw

28. Prostaglandins, Leukotrienes, and Related Compounds, 420 Robert B. Zurier

29. Chemokines and Cellular Recruitment, 437 Gerard Graham

30. Angiogenesis, 445 Ursula Fearon, Zoltán Szekanecz, and Douglas J. Veale

31. Cytokines, 455 Iain B. McInnes

32. Experimental Models for Rheumatoid Arthritis, 467 Rikard Holmdahl

33. Neuronal Regulation of Pain and Inflammation, 480 Camilla I. Svensson and Linda S. Sorkin

Part 4: Broad Issues in the Approach to Rheumatic Disease

34. Clinical Research Methods in Rheumatic Disease, 495 Jeffrey R. Curtis, Yvonne M. Golightly, and Kenneth G. Saag

35. Economic Impact of Arthritis and Rheumatic Conditions, 510 Louise B. Murphy

36. Assessment of Health Outcomes, 522 Dorcas E. Beaton, Maarten Boers, Peter Tugwell, and Lara Maxwell

37. Biomarkers in Rheumatology, 536 Michael J. Townsend, Saloumeh K. Fischer, and Andrew C. Chan

38. Occupational and Recreational Musculoskeletal Disorders, 551 Richard S. Panush

39. Cardiovascular Risk in Inflammatory Rheumatic Disease, 563 Cynthia S. Crowson, Sherine E. Gabriel, and Anne Grete Semb

40. Cancer Risk in Rheumatic Diseases, 579 Eric L. Matteson

41. Introduction to Physical Medicine and Rehabilitation, 592 Sara J. Cuccurullo, Jaclyn Joki, and Ofure Luke

42. Pregnancy and Rheumatic Diseases, 604 Lisa R. Sammaritano and Bonnie L. Bermas

Part 5: Evaluation of Generalized and Localized Symptoms

43. History and Physical Examination of the Musculoskeletal System, 621 John M. Davis III, Kevin G. Moder, and Gene G. Hunder

44. Ultrasound in Rheumatology, 638 Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella

45. Evaluation of Monoarticular and Polyarticular Arthritis, 663 Ronald F. van Vollenhoven

46. Skin and Rheumatic Diseases, 678 David F. Fiorentino and Victoria P. Werth

47. The Eye and Rheumatic Diseases, 702 James T. Rosenbaum

Part 6: Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain

48. Neck Pain, 711 Jennifer Kosty, Rani Nasser, Raul A. Vasquez, Cyrus C. Wong, and Joseph S. Cheng

49. Shoulder Pain, 727 Scott David Martin and Thomas S. Thornhill

50. Low Back Pain, 753 Rajiv Dixit

51. Hip and Knee Pain, 776 James I. Huddleston, III, and Stuart Goodman

52. Foot and Ankle Pain, 792 Christopher P. Chiodo, Mark D. Price, and Adam P. Sangeorzan

53. Hand and Wrist Pain, 800 Kenneth W. Donohue, Felicity G. Fishman, and Carrie R. Swigart

54. Temporomandibular Joint Pain, 813 Daniel M. Laskin

55. Fibromyalgia, 825 Leslie J. Crofford

Part 7: Diagnostic Tests and Procedures in Rheumatic Diseases

56. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology, 841 Hani S. El-Gabalawy and Stacy Tanner

57. Arthrocentesis and Injection of Joints and Soft Tissues, 859 Ahmed S. Zayat, Andrea di Matteo, and Richard J. Wakefield

58. Anti-nuclear Antibodies, 875 Stanford L. Peng and Joseph E. Craft

59. Autoantibodies in Rheumatoid Arthritis, 890 Erika Darrah, Antony Rosen, and Felipe Andrade

60. Acute Phase Reactants, 907 Rebecca Haberman, Cesar E. Fors Nieves, Bruce N. Cronstein, and Amit Saxena

61.Imaging in Rheumatic Diseases, 920 Mikkel Østergaard, Ho Jen, Jacob L. Jaremko, and Robert G.W. Lambert

Part 8: Pharmacology of Anti-rheumatic Drugs

62. Therapeutic Targeting of Prostanoids, 965 Leslie J. Crofford

63. Glucocorticoid Therapy, 985 Marlies C. van der Goes and Johannes W.G. Jacobs

64. Traditional DMARDs: Methotrexate, Lefl, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, 1007 Amy C. Cannella and James R. O'Dell

65. Immunosuppressive Drugs, 1031 Jacob M. van Laar

66. Anti-cytokine Therapies, 1046 Katharine McCarthy, Arthur Kavanaugh, and Christopher T. Ritchlin

67. Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics, 1068 Peter C. Taylor

68. Intra-cellular Targeting Agents in Rheumatic Disease, 1091 Virginia Reddy and Stanley Cohen

69. Urate-Lowering Therapy, 1111 Ted R. Mikuls

70. Bisphosphonates, 1125 Arthur C. Santora II and Kenneth G. Saag

71. Analgesic Agents in Rheumatic Disease, 1135 Gregory R. Polston and Mark S. Wallace

72. Nutrition and Rheumatic Diseases, 1156 Lisa K. Stamp and Leslie G. Cleland

73. Evaluation and Management of Early Undifferentiated Arthritis, 1173 Karim Raza

VOLUME II

Part 9: Rheumatoid Arthritis

74. Etiology of Rheumatoid Arthritis, 1181 Gary S. Firestein

75. Pathogenesis of Rheumatoid Arthritis, 1200 Gary S. Firestein

76. Clinical Features of Rheumatoid Arthritis, 1236 Bryant R. England and Ted R. Mikuls

77. Treatment of Rheumatoid Arthritis, 1258 James R. O'Dell

78. Sjögren's Syndrome, 1284 E. William St. Clair and David L. Leverenz

Part 10: Spondyloarthritis

79. Etiology and Pathogenesis of Spondyloarthritis, 1307 Keith A. Sikora and Robert A. Colbert

80. Ankylosing Spondylitis and Other Forms of Axial Spondyloarthritis, 1319 Sjef van der Linden, Matthew Brown, Lianne S. Gensler, Tony Kenna, Walter P. Maksymowych, and William J. Taylor

81. Reactive Arthritis, 1344 John D. Carter and Alan P. Hudson

82. Psoriatic Arthritis, 1359 Oliver FitzGerald and Conor Magee

83. Inflammatory Bowel Disease-Associated Arthritis and Other Enteropathic Arthropathies, 1381 Richard Zamore, Meenakshi Bewtra, and Alexis Ogdie

Part 11: Systemic Lupus Erythematosus and Related Syndromes

84. Etiology and Pathogenesis of Systemic Lupus Erythematosus, 1396 Mary K. Crow

85. Clinical Features of Systemic Lupus Erythematosus, 1413 Maria Dall'Era and David Wofsy

86. Treatment of Systemic Lupus Erythematosus, 1437 Antonis Fanouriakis, George Bertsias, and Dimitrios T. Boumpas

87. Antiphospholipid Syndrome, 1460 Medha Barbhaiya, Jane E. Salmon, and Doruk Erkan

Part 12: Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes

88. Etiology and...