Jonathan K. Ehrman, PhD, is the associate program director of preventive cardiology at Henry Ford Hospital in Detroit, where he also serves as chair of the institutional review board. He has a 36-year background in clinical exercise physiology and is certified by the American College of Sports Medicine (ACSM) as a clinical exercise physiologist and as a program director. He previously served as the chair of the clinical exercise physiologist credentialing committee for ACSM.

Dr. Ehrman is the author of more than 200 manuscripts and abstracts as well as several textbooks and chapters. He currently serves as editor in chief of the Journal of Clinical Exercise Physiology and was an associate editor of the 10th edition of ACSM’s Guidelines for Exercise Testing and Prescription. He is also the coeditor of the sixth edition of the American Association of Cardiovascular and Pulmonary Rehabilitation’s Guidelines for Cardiac Rehabilitation Programs. He is a fellow of ACSM and the American Association of Cardiovascular and Pulmonary Rehabilitation and is a member of the American Heart Association and the American College of Cardiology. Dr. Ehrman earned his PhD in clinical exercise physiology from The Ohio State University.

Paul M. Gordon, PhD, MPH, is a professor and head of the department of health, human performance, and recreation at Baylor University. He is certified by the American College of Sports Medicine (ACSM) as a clinical exercise physiologist and has over 20 years of experience teaching clinical exercise physiology curricula and directing cardiopulmonary rehabilitation programs. Gordon’s areas of expertise include physical activity and lifestyle-based research related to obesity and its comorbidities across the life span. He has published more than 200 papers and abstracts as well as several chapters, including contributions to ACSM’s Guidelines for Exercise Testing and Prescription. He has also served as an examiner and coordinator for ACSM certification and credentialing.

Dr. Gordon is a fellow of ACSM, the Obesity Society, and the Centers for Disease Control Physical Activity Research Program. He is an international member of the Royal Society of Medicine. He earned his PhD in exercise physiology and an MPH in epidemiology from the University of Pittsburgh.

Paul S. Visich, PhD, MPH, is a professor and chair of the exercise and sports performance department at the University of New England. He has over 20 years of experience in clinical exercise physiology and previously served as director of the Human Performance Laboratory in the College of Health Professions at Central Michigan University. He worked for 12 years in a clinical setting that included cardiac and pulmonary rehabilitation and primary disease prevention. His research interests involve the assessment of cardiovascular disease risk factors in children, the influence of resistance training in elderly populations, and altitude physiology.

Dr. Visich previously served as a member of the American College of Sport Medicine (ACSM) exercise physiology credentialing committee and as chair of their professional education committee. He is the author of more than 70 published scientific articles and abstracts. He earned a PhD in exercise physiology and an MPH in epidemiology from the University of Pittsburgh.

Steven J. Keteyian, PhD, has more than 40 years of experience working as a clinical exercise physiologist. He is program director of preventive cardiology at the Henry Ford Hospital in Detroit. He is also an adjunct professor in the department of physiology at Wayne State University in Detroit. Over the course of his career, Dr. Keteyian has focused on exercise and physical activity in both healthy individuals and those with chronic diseases. He is the author of more than 250 scientific articles and book chapters, as well as four textbooks, and he previously served as editor in chief for ACSM's Health & Fitness Journal.

Dr. Keteyian is a member of the American Association of Cardiovascular and Pulmonary Rehabilitation and the American Heart Association. He earned his PhD from Wayne State University in Detroit.

Part I. Introduction to Clinical Exercise Physiology

Chapter 1. The Profession of Clinical Exercise Physiology
Jonathan K. Ehrman, PhD, Paul M. Gordon, PhD, MPH, Paul S. Visich, PhD, MPH, and Steven J. Keteyian, PhD
The Past, Present, and Future of Clinical Exercise Physiology
Professional Organizations and Certifications Throughout the World
Professionalization of Clinical Exercise Physiology
Conclusion

Chapter 2. Promoting a Physically Active Lifestyle
Anna G. Beaudry, BS, Danielle A. Young, PsyD, and Annie T. Ginty, PhD
Benefits of Physical Activity
Participation in Regular Physical Activity
Conclusion

Chapter 3. General Principles of Pharmacology
Steven J. Keteyian, PhD
General Properties of Drugs
Routes of Administration
Phases of Drug Effect
Mechanism of Action
Pharmacotherapy
Conclusion

Chapter 4. General Interview and Examination Skills
Lizbeth R. Brice, MD
General Interview
Physical Examination
Conclusion

Chapter 5. Graded Exercise Testing
Steven J. Keteyian, PhD
Indications
Contraindications
Procedures for Preparing, Conducting, and Interpreting a Graded Exercise Test
Graded Exercise Testing With Diagnostic Imaging
Conclusion

Chapter 6. Exercise Prescription
Steven J. Keteyian, PhD
Exercise Training Sequence
Goal Setting
Principles of Exercise Prescription
Cardiorespiratory Endurance
Skeletal Muscle Strength and Endurance
Flexibility Training
Conclusion

Chapter 7. Clinical Exercise Programming
Jonathan K. Ehrman, PhD
Cardiac Rehabilitation
Pulmonary Rehabilitation
Supervised Exercise Therapy for Patients With Peripheral Artery Disease
Cancer Rehabilitation
Renal Rehabilitation
General Exercise Programs for Patients With Chronic Disease
Conclusion

Part II. Diseases of the Endocrine System and Metabolic Disorders

Chapter 8. Diabetes
Sheri R. Colberg, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 9. Obesity
David C. Murdy, MD, Dennis J. Kerrigan, PhD, and Jonathan K. Ehrman, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 10. Hypertension
Yin Wu, PhD, and Linda S. Pescatello, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 11. Hyperlipidemia and Dyslipidemia
Paul G. Davis, PhD, Peter W. Grandjean, PhD, Stephen F. Crouse, PhD, and J. Larry Durstine, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 12. Metabolic Syndrome
James R. Churilla, PhD, MPH, MS
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 13. Chronic Kidney Disease
Samuel Headley, PhD, Kenneth Wilund, PhD, and Michael Germain, MD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Part III. Diseases of the Cardiovascular System

Chapter 14. Acute Coronary Syndromes
Ray W. Squires, PhD
Pathophysiology
Clinical Assessment
Exercise Training: Inpatient Cardiac Rehabilitation
Exercise Training: Early Outpatient Cardiac Rehabilitation
Exercise Prescription
Conclusion

Chapter 15. Revascularization of the Heart
Neil A. Smart, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription and Training
Conclusion

Chapter 16. Chronic Heart Failure
Steven J. Keteyian, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 17. Peripheral Artery Disease
Ryan J. Mays, PhD, MPH, Ivan P. Casserly, MB, BCh, and Judith G. Regensteiner, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 18. Cardiac Electrical Pathophysiology
Kerry J. Stewart, EdD, and David D. Spragg, MD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription and Training
Conclusion

Part IV. Diseases of the Respiratory System

Chapter 19. Chronic Obstructive Pulmonary Disease
Satvir S. Dhillon, MSc, Dennis Jensen, PhD, and Jordan A. Guenette, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 20. Asthma
Louis-Philippe Boulet, MD, Simon Bacon, PhD, and Andréanne Côté, MD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 21. Cystic Fibrosis
Kelley Crawford, DPT, CCS
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Part V. Diseases of the Immune System and Oncology

Chapter 22. Cancer
Dennis J. Kerrigan, PhD, and Karen Wonders, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 23. Human Immunodeficiency Virus
Vitor H.F. Oliveira, PhD, MS, Christine Horvat Davey, PhD, RN, and Allison R. Webel, PhD, RN
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Part VI. Disorders of the Bones and Joints

Chapter 24. Arthritis
Melissa Nayak, MD, and Andrew K. Cunningham, MD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 25. Osteoporosis
Lora M. Giangregorio, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 26. Nonspecific Low Back Pain
Peter Ronai, MS
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription and Training
Conclusion

Part VII. Disorders of the Neuromuscular System

Chapter 27. Spinal Cord Injury
Sean M. Tweedy, PhD, Emma M. Beckman, PhD, Mark J. Connick, PhD, Anne L. Hart, PhD, Kati Karinharju, PhD, Kelly M. Clanchy, PhD, and Timothy Geraghty, FAFRM (RACP)
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 28. Multiple Sclerosis
Ulrik Dalgas, PhD, and Lars G. Hvid, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 29. Cerebral Palsy
Désirée B. Maltais, PT, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 30. Stroke
Christopher J. Womack, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Conclusion

Chapter 31. Parkinson’s Disease
Angela L. Ridgel, PhD, and Brandon S. Pollock, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Part VIII. Special Populations

Chapter 32. Children
Timothy J. Michael, PhD, and Carol Weideman, PhD
Definition
Scope
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion

Chapter 33. Older Adults
Jerome L. Fleg, MD, and Daniel E. Forman, MD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription and Training
Conclusion

Chapter 34. Depression
Grace M. McKeon, PhD Candidate, and Simon Rosenbaum, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription and Training
Conclusion

Chapter 35. Intellectual Disability
Tracy Baynard, PhD, and Bo Fernhall, PhD
Definition
Scope
Pathophysiology
Clinical Considerations
Exercise Prescription
Exercise Training
Conclusion