YEAST-BASED CHEMICAL GENOMIC APPROACHES
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation - Chemogenomic Profiling: Elucidating the Mode of Action of Small Molecules
MIRCOARRAY-BASED STRATEGIES TO IDENTIFY UNKNOWN PROTEIN INTERACTIONS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
COMPOUND COLLECTION SYNTHESIS FOR CHEMICAL BIOLOGY
Introduction
Chemical Probes - A Chemical Question with Biological Consequences
Diversity Oriented Synthesis (DOS)
Biology Oriented Synthesis (BIOS)
TARGET IDENTIFICATION AND VALIDATION OF A WNT/BETA-CATENIN PATHWAY MODULATOR
Introduction
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
ACTIVITY-BASED PROTEIN PROFILING OF CYS PROTEASES
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
THE USE OF PHOTOAFFINITY LABELING FOR THE IDENTIFICATION OF THE BINDING SITE OF THE ANTIBIOTIC LINEZOLID
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
SURGICAL STRIKES: USES OF ANALOG SENSITIVE TECHNOLOGIES TO TARGET KINASES OF INTEREST
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation: ASKA Technology - Applications in Molecular Biology
MODULATION OF PROTEIN-PROTEIN INTERACTIONS BY SMALL MOLECULES
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
TARGETED PROTEIN DEGRADATION IN LIVE CELLS
Introduction
The Biological Problem
The Chemical Approach
TRAPOXIN B: FROM TOTAL SYNTHESIS TO EPIGENETICS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
NATIVE CHEMIAL LIGATION - A TOOL FOR CHEMICAL PROTEIN SYNTHESIS
Introduction
The Synthetic Challenge
The Chemical Approach - Native Chemical Ligation
Chemical Biological Research/Evaluation - The Ras-RBD Systems
USING SPLIT INTEINS TO PREPARE SEMI-SYNTHETIC PROTEINS AND TO STUDY THE MECHANISMS OF PROTEIN TRANS-SPLICING
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
ELUCIDATION OF THE RAS CYCLE WITH SEMI-SYNTHETIC PROTEINS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
THE STUDY OF RAB GTPASE RECYCLING USING SEMI-SYNTHETIC PRENYLATED PROTEINS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
DEVELOPMENT OF A MODEL CANCER VACCINE CANDIDATE BASED ON THE MUCl CELLULAR SURFACE GLYCOPEPTIDE EPITOPE
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
THE INTRODUCTION OF CHEMICAL REPORTER GROUPS BY BIOORTHOGONAL LIGATION REACTIONS FOR THE IMAGING OF CELL-SURFACE GLYCANS
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation
SEQUENCE SPECIFIC DNA-BINDING SMALL MOLECULES FOR PROTEIN RECRUITMENT AND MODULATION OF TRANSCRIPTION
Introduction
The Biological Problem - Targeting DNA with Small Molecules
The Chemical Approach: The Polyamide Rationale
Chemical Biological Research/Evaluation - Polyamides in Biological Applications
G-QUADRUPLEX LIGANDS AS TOOLS FOR ELUCIDATING C-MYC TRANSCRIPTIONAL REGULATION
Introduction
The Biological Problem
The Chemical Approach
Chemical Biological Research/Evaluation