Oussama Abla: Acute Promyelocytic Leukemia

Cover: 9783319642567 | Acute Promyelocytic Leukemia | A Clinical Guide | Oussama Abla (u. a.)

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Sprache: Englisch

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Beschreibung

This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.

Über den Autor

Oussama Abla, MD

The Hospital for Sick Children and University of Toronto

Division of Hematology/Oncology

Toronto, ON

Canada

Francesco Lo-Coco, MD

Professor of Hematology

University of Tor Vergata

Rome

Italy

Miguel A. Sanz, MD

Centro de Investigacio¿n Biome¿dica en Red de Cäncer

Madrid

Spain

Zusammenfassung

First comprehensive text on acute promyelocytic leukemia in the last ten years

Summarizes historical, current, and future treatment strategies

Highlights the most recent therapeutic recommendations for relapsed disease

Written by top experts in the field

Inhaltsverzeichnis

History of APL.- Molecular Targets of Treatment in APL.- The Leukemic Stem Cell.- The Molecular Genetics of APL.- APL Coagulopathy.- Early Death in APL.- Prognostic Factors in APL.- First-line therapy for APL: Chemotherapy-based approach.- First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach.- Cure of APL without Chemotherapy.- Minimal Residual Disease in APL.- Treatment of refractory and relapsed APL.- Hematopoietic Stem Cell Transplantation in APL.- APL in Children.- Management of APL in the Elderly.- Special Situations in APL.- APL in Developing Countries: A Chemotherapy-Based Approach.- APL in Developing Countries: ATO based Approach.- Therapy-Related APL.- Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes.- Management of Treatment-Related Complications in APL.

Details

Erscheinungsjahr:	2018
Fachbereich:	Andere Fachgebiete
Genre:	Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Wissenschaften
Medium:	Buch
Inhalt:	xii 274 S. 10 s/w Illustr. 29 farbige Illustr. 274 p. 39 illus. 29 illus. in color.
ISBN-13:	9783319642567
ISBN-10:	3319642561
Sprache:	Englisch
Herstellernummer:	978-3-319-64256-7
Ausstattung / Beilage:	HC runder Rücken kaschiert
Einband:	Gebunden
Redaktion:	Abla, Oussama Sanz, Miguel A. Lo Coco, Francesco
Herausgeber:	Oussama Abla/Francesco Lo Coco/Miguel A Sanz
Auflage:	1st ed. 2018
Hersteller:	Springer International Publishing Springer International Publishing AG
Verantwortliche Person für die EU:	Books on Demand GmbH, In de Tarpen 42, D-22848 Norderstedt, info@bod.de
Maße:	260 x 183 x 21 mm
Von/Mit:	Oussama Abla (u. a.)
Erscheinungsdatum:	11.05.2018
Gewicht:	0,808 kg

Artikel-ID: 111064282